Why the Technology Behind Cancer Gene Panels Matters Genetic screening for inherited cancer risk has become a cornerstone of modern precision medicine. By analyzing specific genes known to influence cancer susceptibility — such as BRCA1 , BRCA2 , TP53 , PTEN , and the mismatch repair genes MLH1  and MSH2  — clinicians can identify individuals at high risk and guide preventive or targeted treatment strategies. The American College of Medical Genetics and Genomics (ACMG)  provi

Proteins are the fundamental building blocks and functional molecules of life. From catalyzing reactions to transmitting signals,...

In the era of big data biology, we are collecting enormous amounts of molecular data from human tissues — from genetic sequences to patterns of chemical modification and regulatory RNA activity. These multi-omics  datasets promise unprecedented insights into disease mechanisms, especially complex diseases like cancer. But making sense of this data requires smart computational tools that can both integrate multiple biological data types  and interpret what the data means . Tha

Optical Genome Mapping is a technique that enables the direct visualization of long DNA molecules to detect structural variants with high...

Epigenetics is the study of heritable changes in gene function that do not involve changes to the DNA sequence. Among the various...

Bioinformatics pipelines are essential for processing and analyzing large-scale biological data. They streamline complex workflows by...

Targeted gene panels, also known as gene-specific panels or custom panels, are a subset of genetic tests designed to analyze specific...

Whole Genome Sequencing (WGS) entails the complete sequencing of an individual's entire genome, encompassing all the nucleotide base...

Whole Exome Sequencing (WES) focuses on the exome – the protein-coding regions of the genome and enables comprehensive analysis of...

In the age of big data, bioinformatics combines biology, computer science, and mathematics, utilizing the power of computational tools...

Fluorescence In Situ Hybridization (FISH) stands out as a powerful technique, from unraveling chromosomal abnormalities to elucidating...

One of the most groundbreaking developments in recent years has been the emergence of long-read sequencing technology. While traditional...

The advent of Next Generation Sequencing (NGS) has revolutionized the way researchers unravel the mysteries of DNA. This cutting-edge...